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Search Results for " fkbp 12 "

Targets

7

Compounds

8

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T13694 FKBP12 PROTAC RC32 RC32 Others
FKBP12 PROTAC RC32 contains conjugation of Rapamycin and a ligand for an E3 ubiquitin ligase.FKBP12 PROTAC RC32 (RC32) is a potent FKBP12 degrader based on PROTAC technology.
T11291 FKBP12 PROTAC dTAG-13 dTAG-13 Epigenetic Reader Domain
FKBP12 PROTAC dTAG-13 (dTAG-13) is a degrader of FKBP12F36V with expression of FKBP12F36V in-frame with a protein of interest. FKBP12 PROTAC dTAG-13 (dTAG-13) also is a selective degrader of BET bromodomain transcription...
T11292 FKBP12 PROTAC dTAG-7 dTAG-7 Epigenetic Reader Domain
FKBP12 PROTAC dTAG-7 (dTAG-7) is a heterobifunctional compound that selectively degrades the BET bromodomain transcriptional co-activator BRD4 by connecting BET bromodomains to the E3 ubiquitin ligase CRBN. Additionally,...
T1784 Everolimus RAD001,SDZ-RAD Apoptosis , Others , mTOR , Autophagy
Everolimus (SDZ-RAD) is a potent mTOR inhibitor that binds to FKBP-12. It is used alone or in combination with calcineurin inhibitors.
T13884 Shield-1 Others
Shield-1 is a specific, high-affinity and cell-permeant ligand of FK506-binding protein-12 (FKBP), and reverses the instability by binding to mutated FKBP (mtFKBP), allowing conditional expression of mtFKBP-fused protein...
T2648 Pimecrolimus SDZ-ASM 981,ASM 981 Others
Pimecrolimus (SDZ-ASM 981), a calcineurin inhibitor immunosuppressant, binds to the receptor macrophilin-12 (FKBP-12) forming a complex that blocks the calcium-dependent signal transduction cascade mediated by calcineuri...
T6033 Zotarolimus ABT-578,A 179578 mTOR
Zotarolimus (ABT-578), an analogue of rapamycin, inhibits FKBP-12 (IC50= 2.8 nM).

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-00808 FKBP12 Protein, Human, Recombinant (His) Human E. coli
FK506 binding protein 12 (FKBP12), also known as FKBP1, along with cyclophilin, are two major members of the immunophilin protein family who serve as receptors for the immunosuppressant drugs cyclosporin A and FK506. As ...
TMPY-01662 FKBP12 Protein, Mouse, Recombinant (His) Mouse E. coli
FK506 binding protein 12 (FKBP12), also known as FKBP1, along with cyclophilin, are two major members of the immunophilin protein family who serve as receptors for the immunosuppressant drugs cyclosporin A and FK506. As ...
TMPY-03385 FKBP14 Protein, Human, Recombinant (His) Human HEK293
FKBP14 belongs to the FK506-binding protein family. It contains 2 EF-hand domains and one PPIase FKBP-type domain. FKBP14 can be detected in the lumen of the endoplasmic reticulum where it is thought to accelerate the fo...
TMPY-03797 Neurofascin Protein, Human, Recombinant (His) Human HEK293
NFASC (Neurofascin, also known as NRCAML, NEDCPMD, and NF) is a Protein Coding gene. 13 alternatively spliced human isoforms have been reported. NFASC belongs to the immunoglobulin superfamily, L1/neurofascin/NgCAM famil...
TMPY-04620 Neurofascin Protein, Human, Recombinant (hFc) Human HEK293
NFASC (Neurofascin, also known as NRCAML, NEDCPMD, and NF) is a Protein Coding gene. 13 alternatively spliced human isoforms have been reported. NFASC belongs to the immunoglobulin superfamily, L1/neurofascin/NgCAM famil...
TMPY-00031 Neuregulin-1/NRG1 Protein, Human, Recombinant (His) Human HEK293
Neuregulin 1 or NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. This growth factor was originally identified as a 44-kD glycoprotein that interacts with the NEU / ERBB2 rec...
TMPY-00479 Neuregulin-1/NRG1 Protein, Human, Recombinant (hFc) Human HEK293
Neuregulin 1 or NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. This growth factor was originally identified as a 44-kD glycoprotein that interacts with the NEU / ERBB2 rec...
TMPY-02642 UBE2W Protein, Human, Recombinant (His) Human E. coli
Ubiquitin-conjugating enzymes, also known as UBE2W, E2 enzymes and more rarely as ubiquitin-carrier enzymes, perform the second step of protein ubiquitination. The modification of protein with ubiquitin is an important c...
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